We’ve heard about the heart health benefits of Coenzyme Q10 (COQ10) for years. But what you might not know is COQ10 turns into Ubiquinol in the body. And it’s not only good for the heart but also for the brain and the rest of your body, even the immune system. I want to talk about the health benefits of COQ10 Ubiquinol and explain some new information about how it helps prevent neurodegenerative problems and diseases. Ubiquinol may potentially be used for the treatment of Alzheimer’s and dementia as part of the treatment strategy.
Dr Dale Bredesen, in his book The End of Alzheimer’s includes Ubiquinol as part of his regimen to reverse cognitive decline (100 mg per day). Why? Because it’s an antioxidant and helps provide energy to cells and also neutralizes free radicals. Free radicals are the enemy, friends. They are rogue cells with one or more unpaired electrons, looking for more to pair with. They wreck all kinds of havoc in the body (and brain) and also can turn into cancer. Oxidative stress creates these free radicals and explains why antioxidants are so important.
How Ubiquinol Works
Ubiquinol is the active form of COQ10. Many people take COQ10 which is converted to Ubiquinol in the body as part of it’s antioxidant process. That’s good! But now Ubiquinol is available in a more direct way to ensure your getting the most out of it.
According to Ubiquinol.org (2020), Ubiquinol is part of the process of tansferring energy to cells, helping the mitochondria, which provide 95% of the energy in cells. So this is critical for organs and muscles, including the heart and brain, to have the energy they need to do their jobs and function well.
A big part of its function, Ubiquinol provides electrons for free radicals, whichs neutralizes their harmful effects.
What’s really interesting to me, is that Ubiquinol is a lipid-soluble antioxidant, whereas Vitamin C, Resveratrol and green tea are water-based antioxidants. Being lipid-soluble means it works in the lipid parts of the body, such as where cell membranes are located (Ubiquinol.org, 2020). Water-soluble antioxidants don’t work in these areas. Vitamin E is also a lipid-soluble vitamin but it actually needs Ubiquinol to help regenerate it. So as you can see, Ubiquinol is an extremely helpful and even critical component of health.
Stough, C. et. al (2019) are conducting a study on COQ10 and Ubiquinol and their effect on cognitive abilities. I’m looking forward to the results. But it has been previously studied and found that mitochondrial dysfunction and oxidative stress are linked to neurodegenerative diseases.
Heart Health and Ubiquinol
There are a large number of studies done on cardiovasular benefits of COQ10 and Ubiquinol. One of the reasons might be because the heart has one of the highest concentrations of COQ10 and Ubiquinol and its benefits for cardiovascular health have been long known. The heart needs a lot of Ubiquinol to maintain it and to function optimally.
In fact, studies have been done with people who had upcoming heart surgeries, took Ubiquinol, and it was found that the heart was able to function much better during and after surgery. Also, there is a lot less mortality in patients suffering with congestive heart failure when taking Ubiquinol. Pretty amazing.
If You’re On A Statin Drug
If you’re on a statin cholesterol-lowering drug, you really need Ubiquinol. Statins destroy the COQ10 in your body. This can lead to adverse muscle-related problems and worse. It is recommended that everyone on a statin drug take Ubiquinol, which is more bioavailable than COQ10. Stough’s group (2019) noted that people taking statins who also took Ubiquinol had much better sustain during exercise.
Brain Health and Ubiquinol
According to Stough et. al (2019), mitochondrial dysfunction is a common underlyer in Parkinson’s Disease, ALS, Hungtinton’s Disease, and Alzheimer’s Disease (AD). They noted a study with palsy patients for six weeks on COQ10. At the end of the study, they found that patients had a definite improvement in cognitive improvement over a placebo group. The researchers found there was an increase in previously lost abilities and that COQ10 helped provide significant clinical improvement.
I found another study by Jun Mitsui et.al (2017) on a three-year followup with patients with Multiple System Atrophy (MSA), another type of neurodegenerative disease. The patients took a high dose of Ubiquinol and PET O2 scans were done before and after. These patients were deficient in COQ10 due to a genetic issue causing their disease.
The images from the PET scans show a remarkable change in their brains. You can see the definite change in structure and the researchers determined that the patients’ mitochondrial oxidative metabolism improved significantly. Also, they felt that this could change the treatment for and lives of people with MSA. It is worth noting the patients dosage was gradually increased to 1200 mg per day and this lasted for over three years. Note: Most people don’t need that high of a dose to see results.
This is extremely encouraging data.
Where We Are Now
Ubiquinol is made in our bodies from COQ10 but taking it as Ubuqiunol increases its bioavailability. We learned that Ubquinol helps the mitochondria get energy into cells so they can function. This is particularly critical for our organs and also muscles. The heart has one of the biggest needs for Ubiquinol but it is now being found that the brain also has high needs for it. Research is ongoing on its role in preventing but maybe even treating neurodegenerative diseases like AD and dementia, Parkinson’s, Huntington’s, ALS and more.
It is apparent that this is a very important supplement. Don’t wait to start supplementing with Ubiquinol to improve your brain and heart health and exercise longer as it helps give your muscles energy too! I’ll include some links to sources I feel good about.
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Kaneka North America LLC. (2020). Ubiquinol.org.
Mitsui J, Koguchi K, Momose T, et al. Three-Year Follow-Up of High-Dose Ubiquinol Supplementation in a Case of Familial Multiple System Atrophy with Compound Heterozygous COQ2 Mutations. Cerebellum. 2017;16(3):664–672. doi:10.1007/s12311-017-0846-9
Stough C, Nankivell M, Camfield DA, et al. CoQ10 and Cognition a Review and Study Protocol for a 90-Day Randomized Controlled Trial Investigating the Cognitive Effects of Ubiquinol in the Healthy Elderly. Front Aging Neurosci. 2019;11:103. Published 2019 May 29. doi:10.3389/fnagi.2019.00103